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Mechanisms of defective insulin secretion in type 2 diabetes Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic and cellula

https://www.ludc.lu.se/education-training/theses/theses-2013/taman-mahdi-hamed - 2025-10-27

Development of protocols for metabolomics in biomedical research using chemometrics Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. Because the metabolite levels in a biological sample are the end result of the regulatory processes in cells, metabolomics is a very powerf

https://www.ludc.lu.se/education-training/theses/theses-2010/anders-danielsson - 2025-10-27

Folate - associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer r

https://www.ludc.lu.se/education-training/theses/theses-2010/ulrika-ericson - 2025-10-27

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/louise-nilsson - 2025-10-27

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/sofia-salo - 2025-10-27

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/annika-lundstig - 2025-10-27

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/anders-h-olsson - 2025-10-27

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https://www.ludc.lu.se/research-0/genomics-diabetes-and-endocrinology/clinical-co-workers - 2025-10-27

Master course in Metabolic diseases BIMM23 (7,5 credits) This course is a master course in the Biomedical programme (Lund University) which focuses on human endocrine and metabolic disorders. The course starts with an introduction to the normal physiology of the endocrine systems and how the organs involved control overall metabolism. The following week, endocrine pathophysiology is studied from d

https://www.ludc.lu.se/education-training/master-course-metabolic-diseases - 2025-10-27

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https://www.ludc.lu.se/research-0/cellular-autoimmunity/previous-co-workers - 2025-10-27

Diabetes Prediction in Skåne The DiPiS study is prospective study that involved screening of all newborn infants in Scania (Skåne) county in southern Sweden for risk factors of Type 1 Diabetes (T1D). The study aims at identifying infants and children in Skåne who are genetically susceptible to T1D (having high risk HLA genes) and to follow these children for 15 years to monitor if they will develo

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/dipis - 2025-10-27

Celiac disease prediction in Skåne The Celiac disease Prediction in Skåne is a spin-off investigation for celiac disease using the DiPiS cohort. It tested to what extent the tissue transglutaminase autoantibodies (tTG IgG or IgA) predict celiac disease (CD). It also tested whether environmental factors other than gluten may initiate the disease process. The genetic factor with the highest risk for

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/cipis - 2025-10-27

The Environmental Determinants of Diabetes in the Young The TEDDY study focuses on studying the role of environmental factors among children who are genetically susceptible to develop T1D. Several environmental factors are incriminated in the etiology of T1D such as gestational and childhood viral infections to such as changes in the gestational environment and infancy feeding, exposure to toxic s

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/teddy - 2025-10-27

Better Diabetes Diagnosis The BDD study is a nationwide prospective cohort study that recruits new-onset T1D who are less than 18 years old at time of diagnosis. There are 40 pediatric medical centers (95% of pediatric centers in Sweden) from most parts of Sweden participating in the BDD study. The BDD study started recruiting new incident patients of T1D from May 1st, 2005 and is still ongoing. C

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/bdd - 2025-10-27

The Global Diabetes Alliance Background The Global Diabetes Alliance (GDA) is a not-for-profit international alliance, established in 2007 and steered by a multinational collaborative panel of leading scientists in the field of diabetes. The GDA is forming a growing ‘virtual diabetes research community’, that is responding to the “tsunami” of diabetes, which threatens the well-being of millions of

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/gda - 2025-10-27

DIAbetes type 1 Prediction, Early Pathogenesis and Prevention The collaborative project DIAPREPP specifically addresses the call FP7 Cooperation Work Programme: Health-2007-2.4.3-1 Early processes in the pathogenesis of type 1 diabetes and strategies for early prevention.  The coordinator is Ezio Bonfacio, Dresden, Germany. The earliest currently identifiable process in the pathogenesis of type 1

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/diaprepp - 2025-10-27

Diabetes Prevention - Immune Tolerance DiAPREV-IT is the first prevention trial with DiamydTM, the alum formulated GAD65 “vaccine”, in children with positive islet cell autoantibodies but not yet diabetes. In the investigator initiated, placebo controlled, and double blind study, children from 4 years of age with positive GAD65-antibodies and at least one more positive islet cell autoantibody will

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/diaprev-it - 2025-10-27

Retinopathy After Diabetes Onset Diabetes retinopathy (DR) refers to any of the vascular changes in the retina. These are observed clinically as microaneurysms, dot and blot hemorrhages, edema, hard and soft exudates, neovascularization and newly formed fibrovascular tissue. The major sight-threatening manifestations of DR, macular edema and proliferative diabetes retinopathy, PDR, are the end res

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/read - 2025-10-27